TMEC · BBD-RSM · v2.0

Response Surface + Statistical Framework

4-factor Box-Behnken · Mixed-effects quadratic · TDV primary endpoint
27
BBD Runs
135
Total N (n=5)
120
df_error
83
Power d=0.50 (adj.)
68
Power d=0.35
15
Model Parameters
5
Tier 1/2 Tests
Holm
MCC Method
Interactive Response Surface
INTERACTION TERM
β_ij coefficient +0.40
⊕ Synergistic interaction
Optimal region
Iso-response contours